Warning: The primary use of Topiramate, and the only use for which it has regulatory approval, is to treat seizures. Its exact mechanism of action is uncertain, but it is known to affect neuronal hyperexcitability,1 which is one probable factor in the development of mraine. Topiramate (Topamax) is an antiepileptic drug recently approved by the U. Food and Drug Administration (FDA) for prevention of mraine headache in adults.
I've been taking Topamax for 2 months now for mraines. I tried to splitting it anyway with a pill cutter but it came out kind of uneven. I experienced a lot of memory problems while I was taking it and it never got better after I got off it. Indicated as adjunctive therapy for seizures associated with Lennox-Gastaut syndrome (LGS) Topamax, Topamax Sprinkles: 25-50 mg/day PO initially; increase by 25-50 mg/day at weekly intervals to 100-200 mg q12hr Trokendi XR, Qudexy XR: 25-50 mg PO q Day initially; increase by 25-50 mg/day at weekly intervals to achieve effective dose; not to exceed 200-400 mg/day Indicated for prophylaxis of mraine headache Titrate over 4 wk to achieve a dose of 50 mg PO BID Week 1: 25 mg PO q HS Week 2: 25 mg PO BID Week 3: 25 mg PO in the morning and 50 mg HS Week 4: 50 mg PO BID Guide dose/titration rate by clinical outcome; if needed, use longer intervals between dose adjustments Orphan desnation for Captisol-enabled topiramate injection for the treatment of partial onset or primary generalized tonic-clonic seizures in hospitalized patients with epilepsy or those being treated in an emergency care setting who are unable to take oral topiramate Decrease in serum bicarbonate (7-67%) Dizziness (4-29%) Fatue (9-16%) Ataxia (6-16%) Nervousness (9-18%) Paresthesia (1-11%) Psychomotor slowing (3-13%) Abnormal vision (2-13%) Anorexia (4-24%) Confusion (4-11%) Decreased memory (2-12%) Nausea (6-10%) Speech disorder (2-13%) Injury (14%) Maintain adequate fluid intake due to kidney stone risk Alcohol use Monitor closely for decreased sweating and increased body temperature; olohydrosis reported with use; monitor during strenuous exercise Concomitant use of drugs that predispose patients to heat-related disorders (such as carbonic anhydrase inhibitors and anticholinergics) Coadministration with valproic acid increases risk of hyperammonemia (with or without encephalopathy) Risk of hypercoremic, non-anion gap, metabolic acidosis; especially if concomitant renal disease, severe respiratory disorder, status epilepticus, diarrhea, surgery, ketogenic diet, or drugs predisposing to acidosis Risks of acute myopia and secondary angle-closure glaucoma (discontinue immediately if vision problems) Visual field defects reported independent of elevated IOP; reversible upon discontinuation Risk of neuropsychiatric disorder; rapid titration rate and hher initial dose were associated with hher incidence Monitor serum bicarbonate at baseline and then periodiy; may also monitor serum coride, ammonia, and phosphorus When discontinuing drug, gradually withdraw to decrease risk of seizure or increased seizure frequency Increased risk in suicidal thoughts/behavior reported; monitor patients for notable changes in behavior and notify healthcare provider if symptoms occur Use caution when operating heavy machinery Hypothermia reported with and without hyperammonemia during topiramate treatment with concomitant valproic acid use Hyperammonemia with or without encephalopathy with monotherapy or in combination with valproic acid reported in patients that have tolerated each drug alone; risk may increase in patients with inborn errors of metabolism or decreased hepatic mitochondrial activity; monitor for vomiting, lethargy, or unusual changes in mental status Infants exposed to topiramate in utero may have an increased risk for cleft lip and/or cleft palate (oral clefts) and for being small for gestational age Pregnancy category: D Cleft lip and cleft palate observed in newborns whose mothers had taken topiramate during first trimester of pregnancy; prevalence of oral clefts was 1.4%, compared with 0.38-0.55% with other antiepileptic drugs (AEDs) and 0.07% with no AED exposure Lactation: Excreted in milk; use caution The above information is provided for general informational and educational purposes only.
Topiramate (or Topamax) is an anti-convulsant medicine.
I have denerative disc disease and my neirologist just prescribed topamax, he said it would help with the pain and tingling but could result in weht loss. Summary Description and Clinical Pharmacology Indications and Dosage Warnings and Precautions Side Effects and Adverse Reactions Drug Interactions, Overdosage, Contraindications, Other Rx Info Active Ingredients User Ratings / Reviews Side Effect Reports Below are Topamax (Topiramate) reviews, ratings, comments submitted by patients and caregivers.
600 comments on the Cite ULike story from Apr 14, 2009, titled Topiramate and Weht Loss... Register and you can start organising your references online. At least for me it sets me back, with the side effects and the headaches.. I was prascribed topiramate 50mg for mraines...1 tablet by mouth at bedtime for 7 days, then take 2 tablets by mouth at bedtime for 21 days...there is 49 pills in the bottle... GENERICA VIAGRA
Rating: 98 / 100
Overall: 90 Rates