Valtrex® 500 24 hours after lesion onset) Suppressive therapy (immunocompetent patients): 1 g/day PO Suppressive therapy (immunocompetent patients with ≤9 recurrences annually): 500 mg/day PO; transmission reduction for source partner, 500 mg/day PO Suppressive therapy (HIV-infected patients): 500 mg PO q12hr Thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) reported in patients with advanced HIV disease and in allogenic bone marrow transplant and renal transplant recipients Acute renal failure (ARF) may occur, especially in elderly patients or those with underlying renal impairment receiving hher than recommended doses; use with caution in patients with renal impairment, the elderly, and/or patients receiving nephrotoxic drugs Treatment should begin with the earliest symptom (tingling, burning, itching) in cold sores; for genital herpes, it should begin at the first sns and symptoms (within 72 hours of onset of first diagnosis or 24 hours of onset of recurrent episodes); for herpes zoster, it should begin within 72 hours of onset of rash; for chicken pox, it should begin with the earliest sn or symptom Central nervous system (CNS) effects may occur (eg, agitation, hallucinations, confusion, encephalopathy); risk of CNS adverse effects is hher in elderly patients Adequately hydrate patient; decreased precipitation in renal tubules may occur Metabolized by liver; valacyclovir is rapidly and nearly completely converted to acyclovir and L-valine via first-pass effect; acyclovir is hepatiy metabolized to a very small extent by aldehyde oxidase and by alcohol and aldehyde dehydrogenase (inactive metabolites) The above information is provided for general informational and educational purposes only.
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Valtrex Tablets 500mg - Summary of Product Characteristics Valtrex is used for treating shingles (herpes zoster), cold sores (fever blisters or herpes labialis), and treating, suppressing, or reducing transmission of genital herpes in patients with normal immune systems.
The dose is 500 mg of Valtrex to be taken twice daily 1000 mg total daily dose. This dose should be reduced according to creatinine clearance see Renal impairment below.
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VALTREX. 500 mg b.i.d. Placebo. Treatment Arm. Source partners were randomized to treatment with either VALTREX 500 mg once daily or placebo once daily for 8 months.
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Product monograph valtrex This dose should be reduced according to creatinine clearance (see Renal impairment below).
Adverse reactions reported by patients receiving VALTREX® 500 mg once daily n=743 or placebo once daily n=741.
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Recurrent Episodes The recommended dosage of VALTREX for treatment of recurrent genital herpes is 500 mg twice daily for 3 days.
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Valtrex is used in adults as well as children for treatment of such infections, caused by herpes viruses, as cold sores, shingles, genital herpes, and.
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